Lean Seafood Intake and Postprandial Metabolism

Ability of a Lean Seafood Diet to Modulate Postprandial Metabolism in Human-beings - a Controlled Intervention Study With Cross-over Design

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01708681

Acronym

LeSIP

Enrollment

Registered

2012-10-17

Start date

2012-10-31

Completion date

2015-09-30

Last updated

2015-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glucose Metabolism Disorders, Hyperlipidemias, Metabolic Diseases, Nutritional and Metabolic Diseases, Nutrition Disorders

Keywords

Seafood, Meat, Egg, Milk, Postprandial lipid metabolism, Postprandial glucose metabolism, Triglycerides, Cholesterol, Postprandial incretins, Postprandial hormones

Brief summary

Despite numerous studies of meal components in humans, little is still known about how different meals influence on metabolism. The purpose of this study is to a gain knowledge of how a balanced test meal with either lean seafood (example:cod) or meat as the main protein source will: 1. affect the postprandial metabolism acutely (test-meal at beginning of the study) 2. affect the postprandial metabolism after 4 weeks controlled intervention (test meal at end of intervention period) 3. affect gut microbiota composition

Interventions

DIETARY_SUPPLEMENTLean seafood

DIETARY_SUPPLEMENTMeat, egg, milk

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* 18-65 years of age * Caucasian

Exclusion criteria

* Smoking * Diabetes * Hysterectomy * Abnormal bleeding last 6 months * Use of medication that affects lipid and glucose metabolism * Large (\>10%) alteration in body-weight the last 6 months * Chronic, metabolic or acute disease or major surgery within last 3 months * Dietary incompatibility with calcium supplementation and/ or seafood consumption (allergy, intolerance, dislike)

Design outcomes

Primary

Measure	Time frame
Postprandial lipid measurement	Change from baseline at 4 weeks

Secondary

Measure	Time frame
Postprandial glucose measurement	Change from baseline at 4 weeks

Other

Measure	Time frame
Postprandial metabolomic measurement	Change from baseline at 4 weeks
Gut microbiota composition	Change from baseline at 4 weeks

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 15, 2026