The Effects of Corneal Collagen Cross-linking

Phase III Study of Corneal Collagen Cross-linking Using Two Different Techniques.

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01708538

Enrollment

Registered

2012-10-17

Start date

2012-10-31

Completion date

2024-10-31

Last updated

2022-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal Ectasia Disorders Including Keratoconus

Keywords

keratoconus, corneal collagen crosslinking, riboflavin, corneal ectasia

Brief summary

The corneal collagen cross-linking treatment has been used with increasing success to treat corneal dystrophies such as keratoconus. Recent advances have allowed different techniques for performing this cross-linking treatment. This study investigates the effects of corneal cross-linking using different surgical techniques.

Interventions

DRUGCXL

corneal crosslinking

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

10 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Age 10-70, willing to participate, diagnosis of corneal ectasia disorder

Exclusion criteria

* Unwilling or unable to participate in trial

Design outcomes

Primary

Measure	Time frame	Description
Visual acuity	1 year	Best corrected Snellen acuity
Keratometry measurements	1 year	Average curvature of the cornea

Countries

United States

Contacts

Primary ContactSloan W Rush, MD

806-353-0125

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 1, 2026