Mechanisms Behind Antidiabetic Effects by Gastric By-pass

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01708096

Enrollment

Registered

2012-10-16

Start date

2009-10-31

Completion date

2013-11-30

Last updated

2014-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus Typ 2 and Obesity

Brief summary

The aim of the study is to develop new strategies in treatment of continuous increasing number of patients with type 2 diabetes by understanding how bariatric surgery cures or improves this condition.

Interventions

DIETARY_SUPPLEMENTModifast

2 weeks before gastric by-pass patients are treated with VLD, 1000 kcal/day

DIETARY_SUPPLEMENTNormal diet

normal diet 2 weeks before gastric by-pass

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Diabetes typ 2 * 18-70 years * BMI \> 35 kg/m2 * Treated with oral antidiabetic agents and/or insulin * laparoscopic surgery

Exclusion criteria

* Pharmacological treatment (other then above) witch could affect glucose metabolism * open surgery

Design outcomes

Primary

Measure	Time frame	Description
Insulin sensitivity	12-18 month after gastric bypass	Insulin sensitivity measured by hyperinsulinemic normoglycemic clamp technique

Secondary

Measure	Time frame
Weight reduction	12-18 month after gastric bypass

Other

Measure	Time frame
Insulin signaling and glucose transport in skeletal muscle	12-18 month after gastric by-pass

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026