Polymorphids an mRNA Expression in Obese Genes

Polymorphids and mRNA Expression in Genes, Significant for Developing Obesity and Typ II Diabetes in Different Types/Localisations of Fat Tissue

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01708083

Enrollment

Registered

2012-10-16

Start date

2010-01-31

Completion date

2013-02-28

Last updated

2013-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mRNA Expression, Polymorphism

Brief summary

Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP). Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 . Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* age 18 years or older * laparoscopic surgery (Gastric by-pass, cholecystectomy, antireflux surgery) * Normal weight without type 2 diabetes BMI 18-25 * Obese without type 2 diabetes BMI\>35 * Obese with type 2 diabetes BMI\>35

Exclusion criteria

* under 18 years * open surgery * pregnancy * BMI \>27-\<35

Design outcomes

Primary

Measure	Time frame	Description
Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity	approximatly 30 minutes after start of operation	fat biopsy taken from abdomen, omenta and thigh at surgery
Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2	approximatly 30 minutes after start of operation	fat biopsy; abdomen, omenta and thigh taken at surgery

Countries

Sweden

Outcome results