Effects of Stress on Glucose Tolerance During Pregnancy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01707784

Enrollment

203

Registered

2012-10-16

Start date

2012-10-31

Completion date

2017-09-30

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational Diabetes, Pregnancy, Stress

Keywords

Pregnancy, Stress, Anxiety, Cortisol, Copeptin, Gestational diabetes

Brief summary

The objective of the study is to investigate the effect of stress on glucose tolerance during pregnancy. The main objectives of the study are to investigate if various measures of stress (stressful life events, the perceived level of stress and the cortisol or copeptin concentrations) differ between pregnant women with and without gestational diabetes during the end of the second/beginning of the third trimester when presenting for their routine glucose tolerance testing. Secondary objectives are the link between these different stress measures and the routinely measured fasting and stimulated glucose levels during the oral glucose tolerance test.

Detailed description

Hypotheses in this study, 3 primary hypotheses will be tested. 1. Women with gestational diabetes have more life events compared to pregnant women without gestational diabetes. 2. Women with gestational diabetes have higher perceived level of stress and anxiety compared to pregnant women without gestational diabetes. 3. Women with gestational diabetes have higher measures of cortisol levels in the saliva and in the nailfolds and higher plasma copeptin levels compared to pregnant women without gestational diabetes. Secondary objectives: 1\. To test the link between these stress measures and the fasting and stimulated glucose levels during the oral glucose tolerance test.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Yes

Inclusion criteria

* All pregnant women who are undergoing a 75 g oral glucose tolerance test at the Maternité of CHUV at 24-30 weeks of gestation between October 2012 and April 2013

Exclusion criteria

* Pregnant woman who has the use if medications that influence either the cortisol and /or the glucose levels * Pregnant woman who has the inability to fill out the questionnaires with assistance

Design outcomes

Primary

Measure	Time frame	Description
Markers of stress	At assessment	stress (stressful life events, the perceived level of stress and the cortisol or copeptin concentrations)

Countries

Switzerland

Outcome results