Genetic Determinant of Blood Pressure Sensitivity to Salt Intake

Clinical, Pharmacological and Biological Investigations of a Polymorphism of Nedd4 , a Regulatory Protein of the Epithelial Sodium Channel

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01706887

Acronym

JEU004

Enrollment

219

Registered

2012-10-15

Start date

2007-04-30

Completion date

2012-03-31

Last updated

2012-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Keywords

Nedd4-2, blood pressure, polymorphism, salt intake, between 18 and 35 years old, BMI between 18 and 28 Kg per m2, no active disease, no alcool or drug abuse or smoke

Brief summary

Nedd4.2 is a regulator of ENac, a transporter of sodium involved in the regulation of salt retention by the kidney. The study address the consequence of a frequent genetic variation leading expected to impact the function of Nedd4 and in turn, the ability of kidneys to excrete salt intake. Our hypothesis is that the genetic variants of Nedd4.2 could constitute a genetic predisposition to (or protection against) salt-sensitive hypertension.

Detailed description

Subjects were submitted one week to a low sodium-high potassium diet, and then switch to a high sodium,-low potassium diet for two weeks. the last week, subject were taken a 20 MG daily dose of amiloride, a potassium sparing diuretic.

Interventions

OTHERDiet Amiloride

only arm of the trial

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers * between 18 and 35 years odl * BMI between 18 and 28 Kg per m2 * non smokers * no active disease * no alcool or drug abuse

Design outcomes

Primary

Measure	Time frame	Description
Difference in Blood Pressure among genotypes	24h AMBP will be measured weekly for the duration of study, an expected average of 3 weeks	24h AMBP will be measured weekly for the duration of study, an expected average of 3 weeks

Secondary

Measure	Time frame	Description
Ambulatory Blood Pressure (AMBP)	three weeks	24h AMBP was measured fourth : at the beginning of the study,at the end of the low sodium-high potassium diet, after one week under the high sodium-low potassium diet and at the end of amiloride treatment under high sodium-low potassium diet

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026