Cesarean Section
Conditions
Keywords
cesarean section, intravenous fluid, a glucose-containing solution, fetal hypoglycemia, neonatal hypoglycemia
Brief summary
The purpose of this study is to investigate the effect of administering a small dose of glucose on the pregnant women and their neonates during cesarean section. We investigate the safety and efficacy of use of a glucose-containing solution for the pregnant women and the neonates.
Detailed description
Rapid infusion of large amount of glucose is associated with fetal hyperglycemia, hyperinsulinemia, and neonatal hypoglycemia. However, the effect of small dose of glucose is unclear. We conducted a pilot study of small dose of glucose. We investigated the effect of a glucose-containing fluid on the blood sugar of the umbilical artery. We found that in the case of no-glucose-containing fluid, there were some cases in which umbilical arterial concentration of glucose was less than 50 mg/dl, which might cause neonatal hypoglycemia. In addition, in the case of 1%-glucose-containing fluid, mean umbilical arterial concentration of glucose was 97 mg/dl. The purpose of this study is to investigate the effect of administering a small dose of glucose on the pregnant women and their neonates during cesarean section. We investigate the safety and efficacy of use of a glucose-containing solution for the pregnant women and the neonates.
Interventions
DRUGadminister acetate Ringer's solution
During cesarean section under spinal anesthesia, each acetate Ringer's solution is administered before delivery.
DRUGacetate Ringer's solution containing no glucose
DRUGacetate Ringer's solution containing 1% glucose
Sponsors
Nagoya City University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing cesarean section who met the criteria of the American Society of Anesthesiologists physical status of 1-2
Exclusion criteria
* ASA physical status \>=3, Obesity (BMI\>35), Height\>=175cm, Weight\>=80Kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The blood glucose concentration in the neonates at one hour of age | One hour of age |
Secondary
| Measure | Time frame |
|---|---|
| The blood glucose concentration in the neonates at two hour of age | Two hour of age |
Other
| Measure | Time frame |
|---|---|
| Evidence of clinical complications (especially, low glucose symptoms) | Within the first 3 days after cesarean section |
Countries
Japan
Contacts
Primary ContactYoshihito Fujita, MD. PhD.
Backup ContactSaya Yoshizawa, MD.
Outcome results
None listed