Cerebral Stroke, Cerebrovascular Accident, Stroke, Acute
Conditions
Keywords
Stroke, Cerebrovascular Accident, HMGB-1, cytokines, functional recovery, inflammation, immune response
Brief summary
The purpose of this study is to measure the presence of HMGB-1 and other proteins in the blood across five time points after stroke, and to determine if their presence correlates with rate of stroke recovery.
Detailed description
Stroke, cerebrovascular accident, is the leading cause of brain injury and the leading cause of permanent disability. The acute pathophysiology of stroke depends on the innate immune response, which arises from mostly pro-inflammatory cascades. The chronic pathophysiology of stroke is less clear as the innate inflammatory response fades and matures into an adaptive immune response. HMGB-1 is a serum cytokine that has been found with persistent elevated levels for weeks to months after neurological insult in preclinical experiments, and may retard functional recovery. Elucidation of the relationship between HMGB-1 levels and the rate of functional recovery after stroke could lead to a better understanding of the systemic inflammatory response and more targeted therapeutic interventions.
Interventions
None listed
Sponsors
Northwell Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to the stroke service at Northshore and LIJ Medical Centers * Patients 18 years of age or older
Exclusion criteria
* Patients \< 18 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine levels (HMGB-1) in plasma samples | day 1, day7, day 14, day 30, day 90 |
Secondary
| Measure | Time frame |
|---|---|
| NIH and Rankin Clinical Measures of functional recovery | day 1, day7, day 14, day 30, day 90 |
Countries
United States
Outcome results
None listed