Respiratory Infection
Conditions
Keywords
human influenza children
Brief summary
The goal of this study is to assess the effectiveness of vitamin D in reducing laboratory-confirmed influenza and in reducing non-influenza viral respiratory tract infections. A cohort of children between the ages of 3 and 17 years from the Thanh Ha Commune, Thanh Liem District, Ha Nam Province, Vietnam will be randomized to either weekly vitamin D supplements or placebo. Participants who develop acute respiratory infection over a 12-month period, will be tested for influenza, the co-primary outcome, and other respiratory viruses, the other co-primary outcome, by RT-PCR.
Interventions
DIETARY_SUPPLEMENTvitamin D supplements
Participants will receive 7mls of D-drops (14,000U/week of vitamin D)
DIETARY_SUPPLEMENTplacebo
7mls of placebo drops per week for 8 months.
Sponsors
McMaster University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
3 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* Between the ages of 3 and 17 * Residing in Thanh Liem District, Ha Nam Province, Vietnam
Exclusion criteria
* Born prematurely at less than 32 weeks gestation * Any chronic illness (except asthma) * Currently using medication known to interfere with vitamin D metabolism * Children with a sibling participating in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Laboratory-confirmed non-influenza infection | 12 months |
| Laboratory-confirmed influenza infection | 12 months |
Countries
Vietnam
Outcome results
None listed