Cancer Patients
Conditions
Keywords
Opioid induced hyperalgesia
Brief summary
Opioid-induced hyperalgesia (OIH) is most broadly defined as a state of nociceptive sensitization caused by exposure to opioids. In humans, the evidence of OIH is strong but conflicting. Previous clinical studies mostly used experimental or non-standardized surgical stimuli to assess OIH. We therefore sought to certify a presence of OIH using a standardized, clinical pain stimuli in cancer patients receiving opioid therapy and opioid-naive patients.
Interventions
PROCEDUREThe local anesthetic injection
Sponsors
Yonsei University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* age 20-80 * cancer patient * patient whom receiving opioid treatment, any acute or chronic pain condition amenable to a diagnostic/therapeutic nerve block or neuromodulation,and a regular analgesic regimen.
Exclusion criteria
* patient who has any change in opioid or other analgesic medications less than 14 days prior to the scheduled procedure * an inability to understand English or adequately respond to the relevant questions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-injection pain intensity | 1 min after lidocaine anesthetic injection | The local anesthetic injection before main procedure was performed by one pain physician using a 25-gauge needle and 1 ml of 1% lidocaine to raise a small skin wheel. Before and immediately following the injection, patients were asked to rate injection-specific pain and unpleasantness intensity on a 0 to 10 numerical rating scale (NRS). |
Countries
South Korea
Outcome results
None listed