Muscular Disorders, Atrophic, Myositis
Conditions
Keywords
Magnetic resonance imaging
Brief summary
A prospective observational study to determine the effectiveness of magnetic resonance (MR) imaging in the diagnosis and monitoring of idiopathic myopathy in adult humans.
Detailed description
Idiopathic inflammatory myopathies are a heterogeneous group of conditions characterised by skeletal muscle inflammation leading to proximal muscle weakness, often with tenderness, and occasionally dermatological manifestations. Diagnosis is clinical and is based on the Bohan and Peter criteria which comprises clinical examination, serological markers, electromyography (EMG) and muscle biopsy. This has relatively poor sensitivity and specificity. Muscle biopsy in particular has a false negative rate of 10-15% and is invasive. Clinical criteria also lack the discriminatory power to differentiate between recurrent (or breakthrough) myopathy and myopathy secondary to treatment with corticosteroid. Magnetic resonance (MR) imaging has the advantage of being non-invasive, and is able to discriminate between different tissues, and to identify areas of inflammation. The aim of this study is to assess the effectiveness of MR sequences in the diagnosis of myopathy, monitoring of treatment response, and in differentiating between breakthrough myopathy and steroid-induced myopathy.
Interventions
PROCEDUREMagnetic Resonance Imaging
Sponsors
West Midlands Comprehensive Local Research Network
University Hospitals Coventry and Warwickshire NHS Trust
Northern Care Alliance NHS Foundation Trust
The Royal College of Radiologists
University of Warwick
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Any adult patient referred for an MR scan with a suspected clinical diagnosis of myopathy.
Exclusion criteria
* Patient unable or unwilling to have an MR scan. * Standard MR
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MR signal (T1w, T2w and STIR sequences) in muscle. | 2 years | The correlation between MR signal and the clinical criteria will be measured |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between MR appearances (T1w, T2w and STIR signal on MR)and the symptom severity (Bohan and Peter criteria) | 2 years |
| Difference in MR signal between myopathy and steroid-induced myopathy, with sensitivity and specificity | 2 years |
Other
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity and specificity of MR against the gold standard of clinical criteria | 2 years | The MR signal will be compared against the Bohan and Peters criteria (the current gold standard) to determine sensitivity and specificity of the technique |
Countries
United Kingdom
Contacts
Primary ContactTerence Jones, MBChB FRCR
Outcome results
None listed