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Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01702779
Acronym
HiFloLUS
Enrollment
80
Registered
2012-10-08
Start date
2011-08-31
Completion date
2013-06-30
Last updated
2014-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Patients Ventilated More Than 48 h, Arterial Line, Consent of Patients, Stable Respiratory and Hemodynamic Conditions for SBT

Keywords

Weaning from mechanical ventilation, Lung ultrasound, Oxygen inhalation therapy

Brief summary

This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Detailed description

Prospective randomized clinical multicentric study on ICU (Intensive Care University) comparing nasal humidified high flow therapy versus standard oxygen with Lung Ultrasound Score during weaning from mechanical ventilation

Interventions

OTHERmechanical ventilation

Prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Sponsors

Pitié-Salpêtrière Hospital
CollaboratorOTHER
University Hospital, Clermont-Ferrand
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adult patients ventilated more than 48 h * Stable respiratory and hemodynamic conditions for SBT * Consent of patients * Arterial line

Exclusion criteria

* COBP * Laryngeal dyspnea * Tracheostomy * Arythmya * No echogenicity * Paraplegia \>T8

Design outcomes

Primary

MeasureTime frame
variations of lung ultrasound score24 hours after extubation

Secondary

MeasureTime frame
Lung ultrasound scoreat baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation
rates of patients with postextubation distressduring the 48th post-extubation
Electrical Impedance tomographyat baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation
Epithelial and endothelial biomarkersat baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026