Povidone Iodine and Cesarean Section Wound Infections

Povidone Iodine 10% Versus 7.5% Hand Scrub and Cesarean Section Wound Infections: A Randomized Trial

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01700803

Enrollment

3231

Registered

2012-10-04

Start date

2012-01-31

Completion date

2012-05-31

Last updated

2012-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wound Infections

Keywords

Betadine, Povidine Iodine, Hand scrubbing, Cesarean section wound infections, post cesarean section

Brief summary

The aim of this randomized clinical trial is to compare the efficiency of hand scrubbing by Povidone-Iodine solution 10% over 7.5% concentration in decreasing post-cesarean section wound infections & compare side effects of both agents.

Detailed description

For centuries, hand washing with soap and water has been considered the main approach for personal hygiene. In the community, hand hygiene has been known to prevent infectious diseases and to decrease the burden of disease. Currently, hand hygiene is considered the most important measure for preventing the spread of pathogens in health-care settings. There are multiple agents used for surgical hand scrubbing as alcohol, chlorhexidine, iodine/iodophors, para-chloro-meta-xylenol & triclosan. Ideally, the optimum antiseptic used for scrub should have broad spectrum of activity, persistent effect & fast acting. Unfortunately most studies evaluating surgical scrub antiseptics have focused on measuring hand bacterial colony counts. No randomized clinical trials have evaluated the impact of surgical scrub choice on surgical site infection risk & proven its efficiency.

Interventions

DRUGPovidone Iodine 10% vand cesarean section wound infections

DRUGPovidone Iodine 7.5% vand cesarean section wound infections

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* elective caesarian section (CS)

Exclusion criteria

* diabetes, * immuno-compromised patients

Design outcomes

Primary

Measure	Time frame	Description
The difference of incidence of surgical site infection between both groups	4 month	Determine the difference in incidence of surgical site infection between Povidone Iodine 10% versus 7.5% hand scrub

Secondary

Measure	Time frame	Description
The difference in the side effects between both groups e.g. dermatitis	4 month	Determine the difference in incidence of side effects between Povidone Iodine 10% versus 7.5% hand scrub

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026