Caries
Conditions
Keywords
Caries, probiotic bacteria
Brief summary
The increasing interest in probiotic lactobacilli in health maintenance has raised the question of potential risks. One possible side effect could be an increased acidogenicity in dental plaque. The aim of this study was to investigate the effect of probiotic lactobacilli on plaque lactic acid (LA) production in vitro and in vivo. Methods. subjects (n=18) were given lozenges with probiotic lactobacilli (L. reuteri DSM 17938 and ATCC PTA 5289) or placebo for two weeks in a double-blinded, randomized cross-over trial. The concentration of LA in supragingival plaque samples was determined at baseline and after 2 weeks. Salivary counts of mutans streptococci (MS) and lactobacilli were estimated with chair-side methods.
Interventions
DIETARY_SUPPLEMENTProbiotic Lactobacilli reuteri
DIETARY_SUPPLEMENTPlacebo
Sponsors
BioGaia AB
Calcin foundation, Denmark
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* moderate to high counts of salivary mutans streptococci (\>104 CFU) as estimated with the Dentocult SM chair-side test, * no visible open caries lesions or periodontal disease,
Exclusion criteria
* smokers, * ingestion of probiotic bacteria within the last two months, * ingestion of antibiotics within the last two months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acid production in plaque after exposure to probiotic bacteria | 2 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Acid producton in plaque after in vitro exposure to probiotic bacteria | 1 hour |
Countries
Denmark
Outcome results
None listed