The Effect of Gastric Bypass Surgery on Gut Hormones Related to Bone Remodeling and Intestinal Growth.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01700686

Enrollment

Registered

2012-10-04

Start date

2011-10-31

Completion date

2014-09-30

Last updated

2014-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Loss, Obesity

Brief summary

The overall purpose is to explore the link between the gut and the bones by investigating meal stimulated changes in the blood level of a number of hormones and markers related to intestinal growth and bone turnover in patients undergoing surgery for obesity (gastric bypass). The hormones will be measured in blood samples taken before and after surgery. The results are compared with changes in body weight and body composition as measured by DEXA scanning.

Interventions

OTHERMeal test and dexa scan

Body composition is determined by whole body deca scan and bone mineral density is determined dy dexa scans of the lumbar spine and the proximal femur.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Caucasians fulfilling the criteria for laparoscopic gastric bypass. * BMI\>40kg/m2.

Exclusion criteria

* Pregnancy * Chronic obstructive pulmonary disease * Diabetes mellitus * Chronic inflammatory bowel disease * Major psychiatric disorder * Drug abuse

Design outcomes

Primary

Measure	Time frame
Meal stimulated changes in gut hormones and bone markers.	Before surgery and 4 weeks and 6 months after surgery.

Secondary

Measure	Time frame
Changes in bone mass and body composition.	Before surgery and 6 months after surgery.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026