Ischemic Heart Disease
Conditions
Brief summary
The purpose is to investigate how the adsorptive capacity of the active carbon filter to carbon dioxide in an anaesthetic gas reflector (AnaConDa) is affected by adding inhaled anaesthetic agent. The hypothesis is that addition of inhaled anaesthetic agent will affect the amount of adsorption of carbon dioxide to the active carbon and thereby affect rebreathing of carbon dioxide.
Interventions
OTHERInhaled anaesthetic agent
Sponsors
Region Skane
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* elective coronary artery by-pass graft surgery * elective valve replacement surgery * normal left ventricular ejection fraction on preoperative echocardiography
Exclusion criteria
* obstructive lung disease * restrictive lung disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Volume of carbon dioxide rebreathing from an anesthetic gas reflector | 2 hours | Tidal carbon dioxide volume rebreathed from an anesthetic gas reflector correlated to concentration of delivered anesthetic gas. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantification of ventilatory requirements to maintain isocapnia with the use of an anesthetic gas reflector. | 2 hours | Changes of tidal volume required to maintain constant alveolar ventilation will be assessed by continuous measurement of exhaled tidal carbon dioxide volume, the latter to be maintained at a constant value. |
Countries
Sweden
Outcome results
None listed