Allergic Asthma
Conditions
Keywords
asthma, allergies, mannitol, methacholine
Brief summary
Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).
Interventions
DRUGMannitol
Indirect bronchoprovocation agent being compared to direct bronchoprovocation agent (methacholine)
Direct bronchoprovocation agent being compared to indirect bronchoprovocation agent (mannitol)
Sponsors
University of Saskatchewan
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* mild, allergic asthma * FEV1 greater than 70% predicted * methacholine PC20 less than or equal to 16mg/ml
Exclusion criteria
* known sensitivity to mannitol or other excipient * diagnosis of any other respiratory or non respiratory disease/disorder that would preclude the individual from participating * recent thoracic, abdominal or eye surgery * recent allergen exposure (4 weeks), respiratory infection (6 weeks) * current immunotherapy * pregnancy * history of anaphylaxis * use of asthma therapies other than short acting beta agonist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in airway responsiveness three hours after allergen exposure | Change from Baseline at 3 hours |
Countries
Canada
Outcome results
None listed