Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy

The Difference Between Central and Peripheral Arterial Blood Oxygen Saturation in Patients Undergoing Cardiac Surgery With Different Cardiopulmonary Bypass Strategy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01698853

Enrollment

Registered

2012-10-03

Start date

2012-10-31

Completion date

2013-05-31

Last updated

2012-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bypass Complications, Disorder of Blood Gas

Brief summary

Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion. Arterial blood gas analysis can help to detect hypoperfusion or hypoxia during retrograde perfusion. However,whether the arterial oxygenation status from different parts of the body are the same in the condition of retrograde perfusion have not been studied. The present study is aimed to determine if there is difference in the arterial oxygenation between peripheral arterial and aortic root during the period of retrograde perfusion.In addition, the impact of artificial ventilation on the difference of arterial oxygenation will also be investigated.

Detailed description

All patients included will be assigned into two different groups according to the surgical approach,one group is named NP with normal perfusion,and the other is named RP with retrograde perfusion. For all the patients,we will obtain 0.5ml blood from both peripheral arterial and aortic root for blood gas analysis at some specific time points. We will focus on the differences of arterial oxygenation between peripheral arterial and aortic root at each group.At the same time,we will analyse the impact of artificial ventilation on it.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age \> 18 years old * undergoing totally thoracoscopic cardiac surgery with cardiopulmonary bypass

Exclusion criteria

* without informed consent * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
The difference between peripheral arterial oxygenation and aortic root blood oxygenation	patients will be followed up during the cardiopulmonary bypass. Blood samples will be collected at 3 timepoints which is specified in the DESCRIPTION	The three time points for blood sample collection are:1.right before clamping the aorta; 2.Three minutes after \\\\ without ventilation;3.5 min after re-initiate mechanical ventilation.

Countries

China

Contacts

Primary ContactMin Chen, M.D.

chenminh@yahoo.com.cn86-13991221157

Backup ContactJing Zhao, M.D.

zhaojing939699@126.com86-13892810471

Outcome results