Collection of Cerebrospinal Fluid in Healthy Children

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01698229

Enrollment

Registered

2012-10-02

Start date

2011-12-31

Completion date

2015-12-31

Last updated

2016-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Batten Disease, Late Infantile Neuronal Ceroid Lipofuscinosis

Keywords

Cerebrospinal fluid, Lumbar puncture, Spinal tap, Late infantile neuronal ceroid lipofuscinosis, Batten disease

Brief summary

The purpose of this study is to obtain cerebrospinal fluid from healthy children already undergoing a lumbar puncture procedure at New York Presbyterian Hospital, to act as healthy controls when compared to children with late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal neurodegenerative disease.

Detailed description

obtain cerebrospinal fluid from healthy children already undergoing a lumbar puncture procedure at New York Presbyterian Hospital, to act as healthy controls when compared to children with late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal neurodegenerative disease.

Interventions

OTHERGroup 1

Collecting a small amount of cerebrospinal fluid (5 mL) from healthy children, ages 2 yrs - 8 yrs, who are already undergoing a lumbar puncture procedure at New York Presbyterian Hospital for clinical or diagnostic purposes.

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

2 Years to 8 Years

Healthy volunteers

Yes

Inclusion criteria

* Males and females, ages 2 yrs to 8 yrs * Children already undergoing a lumbar puncture procedure for clinical or diagnostic purposes

Exclusion criteria

* Presence of any significant neurological diseases, as judged by the co-investigators * Presence of any significant medical conditions including cancer

Design outcomes

Primary

Measure	Time frame	Description
Cerebrospinal fluid (CSF)	1 time point (once)	The primary study endpoint is the metabolic profiling of 32 samples of cerebrospinal fluid from healthy subjects, in comparison to 32 samples of CSF from children with LINCL, to determine whether there are biomarkers found in the cerebrospinal fluid that are associated with LINCL.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026