The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention

Cluster Randomised Trial to Compare Effectiveness of the Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) to LLINs Alone for Malaria Prevention in Muleba District, Kagera Region, Tanzania

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01697852

Enrollment

22300

Registered

2012-10-02

Start date

2011-01-31

Completion date

2012-12-31

Last updated

2012-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria

Keywords

vector control, LLIN, IRS

Brief summary

The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS. Findings from this study are expected to inform decision making so that resource utilization can be optimised.

Interventions

OTHERIndoor residual spraying with bendiocarb

2 rounds of indoor residual spraying with bendiocarb insecticide, 4 months apart

OTHERLLIN by universal coverage campaign

Long lasting Insecticide treated mosquito net

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

6 Months to 14 Years

Healthy volunteers

Yes

Inclusion criteria

* resident in selected cluster (village)

Exclusion criteria

* Not resident in selected cluster (village)

Design outcomes

Primary

Measure	Time frame
Prevalence of malarial infection in children 6 months to 10 years	9 months post randomisation

Secondary

Measure	Time frame
Moderate to severe anaemia in children under 5 years	9 months post randomisation
Post-spraying prevalence of infection with malarial parasites in children 6 months to 10 years	6 months post randomisation

Other

Measure	Time frame
Entomological Innoculation Rate	Malaria season post randomisation(Average value during 6 months after randomisation)
Relative abundance of adult Anopheles mosquitoes by species	Malaria season post randomisation (Average value during 6 months after randomisation)
genotypic markers of insecticide resistance in malaria vector mosquitoes	Malaria season post randomisation (Average value during 6 months after randomisation)

Countries

Tanzania

Contacts

Primary ContactMark Rowland, PHD

Mark.Rowland@lshtm.ac.uk

Backup ContactImmo Kleinschmidt, PHD

Immo.Kleinschmidt@lshtm.ac.uk

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026