Prematurity
Conditions
Keywords
Dexamethasone, preterm labour, respiratory distress
Brief summary
The investigators sought to determine whether the incidence of neonatal respiratory distress syndrome (RDS) in preterm fetuses is similar with 12- vs 24-hour dosing interval of dexamethasone.
Detailed description
The administration of glucocorticoids to accelerate fetal lung maturity in patients with preterm delivery plays an important role for obstetrics and neonatal care. Many studies have shown that maternal administration of glucocorticoids has a significant beneficial effect in decreasing the incidence of respiratory distress syndrome (RDS) in infants delivered at 28-34 weeks of gestation.
Interventions
DRUGDexamethasone 24 hours
DRUGDexamethasone 12
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* All patient with threatened or established preterm labor between 28 - 34 weeks attended to our emergency unit
Exclusion criteria
* emergent obstetric conditions like: * Antepartum hemorrhage in severe attack * Antepartum eclampsia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| respiratory distress syndrome (RDS) | 6 month | determine whether the incidence of neonatal respiratory distress syndrome (RDS) is similar with 12- vs 24-hour dosing interval of dexamethasone. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perinatal mortality | 6 month | Determine whether the incidence of perinatal mortality is similar with 12- vs 24-hour dosing interval of dexamethasone. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Neonatal intensive care | 6 month | Determine whether the incidence of admission to Neonatal intensive care is similar with 12- vs 24-hour dosing interval of dexamethasone. |
Countries
Egypt
Outcome results
None listed