Intestinal Insufficiency, Short Bowel Syndrome
Conditions
Keywords
Gastrointestinal drugs, Antibiotics, Vitamins, Minerals, Intestinal insufficiency, Short Bowel syndrome, Adjuvant therapy, Antacids, Gastrointestinal motility modifiers, Micronutrients
Brief summary
Intestinal insufficiency due to short bowel syndrome is a chronic, disabling condition with significant morbidity and mortality.Standard care includes home parenteral/enteral nutrition as well as intestinal transplantation, however multiple drugs, vitamins, antibiotics and symptom-relieving agents may be required. Prescriptional pattern of these drugs will be analyzed in a clinical cohort.
Detailed description
Intestinal insufficiency due to short bowel syndrome is a chronic, disabling condition with significant morbidity and mortality.Standard care includes home parenteral/enteral nutrition as well as intestinal transplantation, however multiple drugs, vitamins, antibiotics and symptom-relieving agents may be required. Little attention has been given to the indications and dosage schedules of such drugs, many of which are employed as off-label prescriptions because of lack of official guidelines. Prescriptional patterns of these drugs will be analyzed in a clinical cohort of home parenteral/enteral nutrition patients, registered at the outpatient service of Hospital das Clinicas, Sao Paulo, Brazil.
Interventions
DRUGDrug prescription pattern
Type, dosage, administration route and frequency of prescription of all adjuvant pharmacologic agents will be transcribed from hospital records
Sponsors
University of Sao Paulo
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Home nutritional support longer than 12 months,full records and return visits available at the hospital system. \-
Exclusion criteria
Critical illness, death, discontinuation of nutritional therapy, registered for intestinal transplantation, additional gastrointestinal operations for short bowel syndrome (valves, lengthening) or for other conditions (gallbladder disease, intestinal obstruction, necrosis, infection). \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major gastrointestinal adjuvant prescription | Last 12 months | The most prescribed adjuvant agent for alleviation of gastrointestinal troubles such as diarrhea, malabsorption or gastric hypersecretion. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Major antibiotic adjuvant prescription | Last 12 months | Principal antibiotic employed for suspected or actual bacterial overgrowth associated with diarrhea, malabsorption or systemic aberrations. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Main vitamin/mineral adjuvant prescription | Last 12 months | Vitamin, mineral or other micronutrient required for correction of nutrition deficiency, not available or poorly absorbed via current parenteral/enteral nutrition regimen |
Countries
Brazil
Outcome results
None listed