Vitamin D Deficiency
Conditions
Keywords
vitamin D, bioeffiency, vitamin d fortified fish
Brief summary
The aim of this study is to investigate the bioavailability of conventional and vitamin D fortified fish as measured by the increase of the specific hydroxy form by 25(OH)D3.
Detailed description
Study design: Human volunteers will receive conventional fish or vitamin D fortified fish for a period of 4 weeks. At baseline and after 4 weeks, 25(OH)D3 will be measured in serum as the main outcome variables. Additional outcome variables are the Ca concentration in serum, PTH concentration in serum. Groups/Cohorts Assigned Interventions 1. Placebo group receiving conventional fish 2. intervention group receiving vitamin D fortified fish
Interventions
OTHERvitamin D fortified fish
fish containing vitamin D3
OTHERconventional fish
fish containing low concentrations of vitamin D3
Sponsors
Ulrike Lehmann
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years * healthy
Exclusion criteria
* supplementation of vitamin d and calcium * hypercalcemia * hypercalciuria * chronical illness (diabetes, kidney diseases, cardiovascular diseases) * serum-creatinine above 115 mmol/l * pregnancy or breastfeeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of 25-hydroxvitamin D | after 4 weeks of consumption |
Countries
Germany
Outcome results
None listed