Effects of High and Low Frequency TENS on Sympathetic Skin Response and Skin Temperature

The Effects of High and Low Frequency Transcutaneous Electrical Nerve Stimulation on Sympathetic Skin Response and Skin Temperature

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01696149

Enrollment

Registered

2012-09-28

Start date

2010-03-31

Completion date

2011-06-30

Last updated

2012-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of TENS on Sympathetic Skin Response

Keywords

TENS, sympathetic skin response, skin temperature

Brief summary

The aim of this study was to determine the effects of 4 Hz and 110 Hz transcutaneous electrical nerve stimulation on the sympathetic nervous system via measuring the sympathetic skin response (SSR) and skin temperature.

Detailed description

15 healthy subjects (8 females, 7 males) with a mean age of 22.6 ± 3.7 years participated in this study. All subjects participated, randomly, in a 4 Hz TENS session, a 110 Hz TENS session, and a control (off-TENS) session. Each session consisted of a 20- minute stimulation period and a 10-minute follow up period. Outcome measures: Sympathetic skin response from the simulated (Right) hand and skin temperature of both stimulated (Right) and none stimulated (Left) hand was measured 15 seconds before, just 15 seconds after, and 10 minutes after application of interventions.

Interventions

DEVICEtranscutaneous electrical nerve stimulation

All subjects participated, randomly, in a 4 Hz TENS session, a 110 Hz TENS session, and a control (off-TENS) session. Each session consisted of a 20- minute stimulation period and a 10-minute follow up period.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 30 Years

Healthy volunteers

Inclusion criteria

* Men and women aged 18 to 30 years

Exclusion criteria

* History of cardiovascular, neurologic or musculoskeletal disease * Taking medication at the time of the study

Design outcomes

Primary

Measure	Time frame	Description
Changes of sympathetic skin response	15 seconds before, just 15 seconds after, and 10 minutes after application of interventions	Sympathetic skin response from the simulated (Right) hand was measured 15 seconds before, just 15 seconds after, and 10 minutes after application of interventions.

Secondary

Measure	Time frame	Description
Changes of skin temperature	15 seconds before, just 15 seconds after, and 10 minutes after application of interventions	skin temperature of both stimulated (Right) and none stimulated (Left) hand was measured 15 seconds before, just 15 seconds after, and 10 minutes after application of interventions

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026