Brain Perfusion and Hemodynamic Stability in Patients Undergoing Radiofrequency Ablation of Ventricular Tachycardia

Assessment of Intracardiac and Surgace Electrogram Characteristics Correlated to Brain Perfusion and Hemodynamic Stability in Patients Undergoing Radiofrequency Ablation of Ventricular Tachycardia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01695551

Enrollment

Registered

2012-09-28

Start date

2012-07-31

Completion date

2016-12-31

Last updated

2017-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventricular Tachycardia

Keywords

Radiofrequency ablation, fast heart rhythm, ventricle, catheter ablation, ablation

Brief summary

Ventricular tachycardia (VT) is a life-threatening, fast heart rhythm that starts in the lower chambers of the heart (the ventricles). This fast heartbeat is caused by abnormal electrical pathways located in the heart tissue. A standard procedure called a catheter ablation has been used for several years to help correct these abnormal pathways and, in some cases, improve or even eliminate the ventricular tachycardia. During a VT ablation it is routine to monitor your vital signs (blood pressure, heart rate, and oxygen saturation in your blood). If you choose to participate in this study we will also monitor your cerebral oximetry, the amount of blood flow and oxygen saturation to your brain during the ablation. By doing this study, we hope to have a better understanding of patients' blood and oxygen flow to their brain during an episode of Ventricular Tachycardia (VT).

Interventions

OTHERData Collection Forms

Participants will be asked questions relating to pre-procedure items and be asked to complete an MMSE. Subjects receive standard of care surgery. Data collected from procedures before, during and after surgery.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Able to give informed consent * Have implantable defibrillator in-situ and are undergoing ablation procedure for ventricular tachycardia

Exclusion criteria

* Patients who have been hypotensive with systolic blood pressure of \< 80mm Hg prior to procedure * Cerebral event as defined by Cerebrovascular Accident or Transient Ischemia Attack within six months prior to procedure

Design outcomes

Primary

Measure	Time frame	Description
Identify clinical, EKG and EGM characteristics of hemodynamically unstable VT	Change from Baseline to 24-48 hours after surgery	The investigator will be evaluating the relationship of the oxygenation level of the brain during a Ventricular Tachycardia ablation.

Secondary

Measure	Time frame	Description
MMSE to determine cerebral function before and after VT ablation	24 hours after surgery	The use of the Mini-Mental Status Exam prior to the ablation will serve as a reference point and will be repeated 24 hours post exam.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026