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Cognitive Behavioral Therapy for COPD

Psychosocial-Behavioral Therapy for Patients With Advanced COPD and Depression

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01694628
Acronym
CLIMB
Enrollment
18
Registered
2012-09-27
Start date
2012-09-30
Completion date
2016-10-31
Last updated
2021-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Depression

Brief summary

The purpose of this study in patients with advanced COPD and depression is twofold: 1. Determine the feasibility and acceptability of a 6-session e-counseling intervention 2. Determine the efficacy of the e-counseling intervention on depressive symptoms We hypothesize that patients who participate in e-counseling will have improved depressive symptoms compared to patients receiving usual care at 8 weeks.

Detailed description

Chronic obstructive pulmonary disease (COPD) is the third leading cause of the death in the US. Although COPD is mostly preventable, there is no cure. Thus, care of patients with COPD is primarily focused on symptom palliation with the goal of improving quality of life for both patients and their families. These goals are highly consistent with core principles of palliative care. Dyspnea is the most distressing symptom for patients. Even optimal disease-directed treatment provides only partial relief from dyspnea. Depression is consistently associated with worse dyspnea, but the mechanisms underlying this relationship are poorly understood. Since existing treatment for dyspnea has only limited success and there is evidence that treating depression alleviates pain, we propose that by improving mood, we may be more successful in alleviating dyspnea. Psychosocial-behavioral therapy (PBT) which is focused on increasing pleasant events and improving problem solving skills has been shown to have immediate and sustained effects on depressive symptoms in patients with dementia and post-stroke holds tremendous promise for efficacy in advanced COPD. Testing the use of novel technologies to provide efficacious interventions such as PBT to patients with advanced disease is critical for translational palliative care research

Interventions

BEHAVIORALCLIMB (COPD Lifestyle, Mood, and Behavior)

Cognitive Behavioral Therapy delivered to patients via telephone aimed to improve mood and decrease depressive symptoms.

Sponsors

Icahn School of Medicine at Mount Sinai
CollaboratorOTHER
University of Washington
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* COPD (FEV1/FVC \< 70% & FEV1 \<80%; current or past smoking \>10pack-years) * Depressed (PHQ-9 \>=10) * Ability to speak, read and write English * Willingness to use computer or study-issued tablet device

Exclusion criteria

* Current non-nicotine substance abuse or dependence * Psychotic disorder * Active suicide ideation with intent and plan * Alzheimer's/dementia * Currently receiving any psychotherapy

Design outcomes

Primary

MeasureTime frameDescription
Depressive Symptoms8 weeksPersonal Health Questionnaire-9

Secondary

MeasureTime frameDescription
Dyspnea Intensity and Distress8 weeksChronic Respiratory Questionnaire, Shortness of Breath Questionnaire, Dyspnea Management Questionnaire
Fatigue8 weeksChronic Respiratory Questionnaire
Anxiety8 weeksHospital Anxiety and Depression Scale
Physical Activity8 weeksAccelerometry (Stepwatch)
Quality of Life8 weeksChronic Respiratory Questionnaire and Medical Outcomes Short Form-36

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026