Coronary Artery Disease
Conditions
Keywords
Near infrared spectroscopy; lipid core; vulnerable plaque
Brief summary
To characterize atherosclerotic coronary artery plaques using advanced intra-coronary imaging with a combined near-infrared spectroscopy and intravascular ultrasound catheter before and after percutaneous intervention
Detailed description
This study is being performed to characterize the composition and morphologic characteristics of atherosclerotic coronary artery plaques with intra-coronary near-infrared spectroscopy and intravascular ultrasound in patients undergoing percutaneous coronary intervention.
Interventions
None listed
Sponsors
Corewell Health West
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Subject is at \> 18 years of age 2. Subject presents to the catheterization laboratory to undergo clinically-indicated, invasive coronary angiography 3. Subject is willing and able to provide informed written consent 4. Subject is found to have ≥ 1 severe coronary artery stenosis by invasive angiography and percutaneous coronary intervention is planned for definitive treatment or found to have ≥ 1 intermediate coronary artery stenosis and IVUS planned for lesion assessment 5. Coronary anatomy is deemed suitable for combined NIRS-IVUS by the interventional cardiologist performing invasive angiography and intervention
Exclusion criteria
1. Subject is pregnant or suspected to be pregnant 2. Subject is unable to provide informed consent 3. Subject has coronary artery anatomy deemed by interventionalist as unsuitable for NIRS-IVUS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MACCE | 5 year |
Countries
United States
Outcome results
None listed