Study on the Effect of Fish Oil and Appetite

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01692990

Enrollment

Registered

2012-09-26

Start date

2011-10-31

Completion date

2011-11-30

Last updated

2012-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cachexia, Obesity

Keywords

Appetite, Fish oil, Long-chain n-3 fatty acids

Brief summary

20 normal-weight healthy subjects (10 males, 10 females) were in two periods given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.

Detailed description

In a randomized cross-over design, 20 normal-weight healthy subjects (10 males, 10 females) were given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.

Interventions

DIETARY_SUPPLEMENTFish oil

For 3 weeks 5 g/d in 10 capsules, providing 3.5 g long-chain n-3 fatty acids in the fish oil period. Cross-over between arms with 1 week of wash out

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Normal weight (18.5\<BMI\<25 kg/m2). * Healthy.

Exclusion criteria

* Subjects taking medication that could influence appetite. * Subjects with special nutritional needs e.g. pregnant and lactating, seriously ill or old people. * Subjects that had had fish oil-supplements for four weeks prior to the intervention period.

Design outcomes

Primary

Measure	Time frame	Description
Appetite and satiation	October 7th - November 25th 2011	Appetite and satiation were measured by visual analogue scales (VAS), which assessed satiation, hunger, fullness and desire to eat. Each scale was 100 mm in length with words anchored at each end, expressing the most positive and negative rating of each category.

Secondary

Measure	Time frame	Description
Weight change	October 7th - November 25th 2011	Body weight was measured on the same scale without shoes and wearing light clothing in the morning before breakfast.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026