Prognostic Value Related to the Presence of Thrombosis or Portal Vein Invasion in Patients With Hepatocellular Carcinoma Submitted to Surgery

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01690715

Acronym

HSL2012-06

Enrollment

Registered

2012-09-24

Start date

2012-07-31

Completion date

2012-08-30

Last updated

2023-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatic Portal Vein Tumor Invasion, Hepatocellular Carcinoma, Portal Vein Thrombosis

Keywords

Hepatocellular Carcinoma, Thrombosis, Portal Vein Invasion

Brief summary

A retrospective study based on analysis of medical records of patients with hepatocellular carcinoma treated at the Hospital Sírio-Libanês (Sao Paulo-Brazil) between 2001 and 2011 with diagnosis confirmed by imaging or histological specimen underwent surgical resection with curative intent. The study aims to determine the prognostic value of vascular complications related to cancer and to evaluate the survival rate of these patients, comparing the data with those reported in the literature.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* hepatocellular carcinoma confirmed by imaging or histological specimen underwent surgical resection, with or without hepatic cirrhosis association; * presence of venous outflow obstruction, either by direct tumor invasion or thrombosis, on portal vein or one of its main vessels;

Exclusion criteria

* Patients undergoing prior systemic treatment; * Patients presenting incomplete data that do not allow their classification according to the stratification models; * Patients whose information of progression or death can not be recovered;

Design outcomes

Primary

Measure	Time frame	Description
Prognosis (disease graduation)	1 to 3 years	The carcinoma prognosis in the presence of vascular complications related to cancer, characterized by invasion or portal vein thrombosis.

Secondary

Measure	Time frame	Description
Survival rate in years	1 to 3 years	Determination of the survival rate within 1 to 3 years for those submitted to curative hepatectomy.
Relation established between survival and degree of underlying liver dysfunction	1 to 3 years	Investigate a possible relationship between survival and degree of underlying liver dysfunction in patients with thrombosis or portal vein invasion in patients undergoing curative hepatectomy.

Countries

Brazil

Outcome results