Blood Pressure Regulation
Conditions
Keywords
rifampicin, pregnane X receptor, blood pressure
Brief summary
We are investigating the effects of pregnane X receptor (PXR) activation on the regulation of blood pressure in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator) and placebo will be given for a week to volunteers and blood pressure is measured 24 hours using an ambulatory blood pressure monitor. Blood pressure regulating hormones will be measured in blood. Our hypothesis is that PXR is involved in the regulation of blood pressure.
Interventions
DRUGRifampicin
DRUGPlacebo
Sponsors
Oulu University Hospital
University of Oulu
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * BMI 19-30 kg/m2 * Age 18-40 years * Systolic blood pressure 95 - 140 mmHg
Exclusion criteria
* Any continuous medication * Any significant medical condition as judged by the study physician * Diastolic blood pressure over 90 mmHg * Sensitivity to rifampicin * Pregnancy and lactation * Difficult venipuncture * Abuse of alcohol or medications, or drug use. * Participation in other trial with medications in previous 30 days
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systolic ambulatory blood pressure | On day 8 of each arm | Systolic blood pressure measured with ambulatory blood pressure monitor. |
| Diastolic ambulatory blood pressure | On day 8 of each arm | Diastolic blood pressure measured with ambulatory blood pressure monitor |
Secondary
| Measure | Time frame |
|---|---|
| Systolic and diastolic blood pressure | On day 9 of each arm |
| Pulse (ambulatory) | On day 8 of each arm |
| Plasma renin activity | On day 9 of each arm |
| Serum aldosterone | On day 9 of each arm |
Countries
Finland
Outcome results
None listed