Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

Comparison of Furosemide/Fludrocortisone With Ammonium Chloride Loading Test in the Diagnosis of Incomplete dRTA in Kidney Stone Formers

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01690039

Enrollment

170

Registered

2012-09-21

Start date

2012-09-30

Completion date

2017-05-12

Last updated

2018-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acidosis, Renal Tubular, Nephrolithiasis, Vacuolar Proton-Translocating ATPases

Keywords

renal tubular acidosis, V-ATPase, kidney stones

Brief summary

Purpose 1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test. 2. To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.

Interventions

DRUGFurosemide-Fludrocortisone-Test (test for urinary acidification)

The presence of a lack of urinary acidification will be assessed by an appropriate test in all patients.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* One or more episodes of nephrolithiasis

Exclusion criteria

* Absence of informed consent * All conditions affecting renal acidification * Pregnancy * Nursing

Design outcomes

Primary

Measure	Time frame
Capability of urinary acidification	Five to six hours

Secondary

Measure	Time frame
Polymorphisms in the ATP6V1 gene	12 months

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026