Klinefelter Syndrome, Mental Disorders, Physical Disorders, Quality of Life
Conditions
Brief summary
Klinefelter syndrome is the most common sex-chromosome disorder in men with a prevalence of 1 in 660 men. The syndrome is associated with hypogonadism. Many patients with Klinefelter syndrome have psychological complaints and physical discomfort. Some patients report a positive effect of testosterone treatment, whereas others do not. The aim of this study is: (i) To investigate quality of life in patients with Klinefelter syndrome. (ii) To investigate functional, physical and mental health in patients with Klinefelter syndrome. Questionnaire concerning mental and physical health and life quality are sent out to patients with KS and to age-, educational- and zipcode-matched men from the general population. The questionnaire include questions about housing, income, marital status, fatherhood, medication, chronic disease,school and education, attachment to the labor, sexual and erectile function, life quality, mental and physical health, satisfaction with life and symptoms of attention deficits hyperactivity disorders.
Interventions
None listed
Sponsors
Aarhus University Hospital
University of Aarhus
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
For the Klinefelter group: Inclusion Criteria: * Verified Klinefelter syndrome
Exclusion criteria
* none For the control group: Inclusion Criteria: * age-,educational,and residence-matched
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life | 3 month | Quality of life score is measured with the WHOQOL-Brief questionnaire |
| Satisfaction with life | 3 month | Satisfaction with life is measured with the SWLS - Satisfaction with Life Scale |
| ADHD symptoms | 3 month | ADHD symptoms are measured by Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist |
| General health | 3 month | General health is measured by SF-36 questionnaire |
| Erectile function | 3 month | Erectile function is measured by the International index of erectile function (IIEF-5) as a diagnostic tool for erectile function. |
Other
| Measure | Time frame | Description |
|---|---|---|
| School and educational | 3 month | Information about school and education |
| Marital status | 3 month | — |
| Attachment to the labor | 3 month | working position, working hour, period of sick leave |
| Income | 3 month | — |
| Medication | 3 month | — |
| Chronic disease | 3 month | — |
| Housing | 3 month | — |
| Fatherhood | 3 month | — |
Countries
Denmark
Outcome results
None listed