Diabetes Mellitus Type 1, Diabetic Maculopathy
Conditions
Brief summary
The primary objective is to study if an inhibition of nitric oxide and/or prostaglandins affect the diameter changes of retinal vessels observed during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.
Interventions
OTHERCOX inhibitor
Administration of 1 drop voltaren 45 minutes before recordings of diameter changes of retinal vessels are initiated
OTHERL-NG-monomethyl arginine citrate
Intravenous administration of L-NMMA during recordings of diameter changes of retinal vessels
OTHERCOX inhibitor + L-NG-monomethyl arginine citrate
Combination of interventions. Administration of an eye drop voltaren and 45 minutes later infusion with L-NMMA is started and recording of diameter changes of retinal vessels is performed
Sponsors
University of Aarhus
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Diabetes type 1 without retinopathy * Diabetic retinopathy
Exclusion criteria
* Cardio-vascular disease * Lung disease * Pregnancy * Previous ocular disease other than retinal branch vein occlusion * Previous treatment with medications influencing on the intraocular pressure or the metabolism of nitric oxide or prostaglandins
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diameter changes of retinal vessels | Examination day 1 and 2 | Comparing the differences of diameter changes occuring during each of the interventions. |
Countries
Denmark
Outcome results
None listed