Immune Response in the SAPHO Syndrome

Immune Mechanisms During SAPHO Syndrome and Treatment by Etarnecept

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01688219

Enrollment

Registered

2012-09-19

Start date

2005-11-30

Completion date

2008-05-31

Last updated

2012-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SAPHO Syndrome

Keywords

SAPHO syndrome, Innate immunity, TNF alpha, Polymorphonuclear neutrophils, Propionibacterium acnes, Interleukin-8

Brief summary

The aetiology of SAPHO syndrome seems to involve genetic, infectious and immunological components. The investigators examined innate and adaptative immune responses in SAPHO syndrome as compared with psoriatic arthritis and rheumatoid arthritis.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of SAPHO syndrome * Must have bone lesions

Exclusion criteria

* Infliximab treatment

Design outcomes

Primary

Measure	Time frame
IL-8 production by PMN	24 h

Secondary

Measure	Time frame
TNFalpha production by PMN	24 h

Outcome results