Vasopressin to Prevent Hypotension During Beach Chair Surgery

Clinical Trials of Vasopressin for Prevention of Hypotension During Shoulder Surgery in Beach Chair Position Under General Anesthesia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01687894

Enrollment

Registered

2012-09-19

Start date

2012-05-31

Completion date

2014-12-31

Last updated

2017-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rotator Cuff Tear Arthropathy

Keywords

cerebral oxygen saturation, beach chair position, hemodynamic, jugular venous oximetry

Brief summary

Patients undergoing surgery in beach chair position (BCP) are at risk for cerebral ischaemia. The impacts of arginine vasopressin (AVP) on haemodynamics and cerebral oxygenation are evaluated during surgery in BCP.

Detailed description

Patients undergoing shoulder surgery in BCP under general anaesthesia are randomly allocated to receive i.v. normal saline (control group) or AVP 0.05 or 0.07 U kg-1 (AVP group, n = 15 each) 2 min before moving into BCP. Mean arterial pressure (MAP), heart rate (HR), jugular venous bulb oxygen saturation (SjvO2) and regional cerebral tissue oxygen saturation (SctO2) are measured before (pre-sitting in supine position) and after patients assumed BCP.

Interventions

DRUGsevoflurane

vasopressins sevoflurane placebo sevoflurane

DRUGVasopressins

Vasopressins propofol vasopressins sevoflurane

DRUGPlacebo

Placebo propofol & placebo sevoflurane

DRUGpropofol

vasopressin propofol & placebo propofol

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

elective arthroscopic shoulder surgery under general anesthesia in beach chair position

Exclusion criteria

preexisting cerebrovascular diseases, history of orthostatic hypotension, age less than 18 yr, and the American Society of Anesthesiologists physical status IV or V

Design outcomes

Primary

Measure	Time frame	Description
The magnitude of decrease of mean arterial pressure	Baseline (before positioning) and lowest value within 10 min into beach chair position	Continuously measure mean arterial blood pressure before and after position change. Calculate the magnitude of maximum decrease of mean arterial pressure from baseline

Secondary

Measure	Time frame	Description
Jugular venous oxygen desaturation	Up to 30 min after the positioning	Jugular venous oxygen saturation is continuously measured whether its saturation is decreased below 50% or/and 40% for longer than 5 min.

Other

Measure	Time frame	Description
Cerebral oxygen desaturation	Up to 30 min after the position change	Continuously observe near-infrared spectroscopy measured cerebral oxygenation before and after beach chair position whether oxygen saturation decrease more than 20% from pre-sitting values

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 10, 2026