Evaluation of Efficacy and Safety of General Anesthesia Using Dexmedetomidine With Sevoflurane in Patients Undergoing Arthroscopic Shoulder Surgery: Preliminary Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01687868

Enrollment

Registered

2012-09-19

Start date

2012-07-31

Completion date

2013-05-31

Last updated

2014-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthroscopic Shoulder Surgery in the Beach-chair Position

Brief summary

Patients undergoing shoulder arthroscopy in the beach chair position may be at risk for adverse neurologic events due to cerebral ischemia. Dexmedetomidine, a potent alpha adrenoceptor agonist which dose-dependently reduces arterial blood pressure and heart rate, decreases the hemodynamic and catecholamine response in the perioperative period. dexmedetomidine has an effect of peripheral vasoconstriction thus it is theologically appropriate for reducing bleeding for arthroscopic operation field. The aim of this study is to evaluate the efficacy and the safety of dexmedetomidine on cerebral oxygen saturation, cognitive function, hemodynamic stability and operative field in patients undergoing arthroscopic shoulder surgery in the beach-chair position.

Interventions

DRUGDexmedetomidine

dexmedetomidine 0.7mcg/kg/hr continuous infusion

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* ASA I-II * Aged between 20 and 70 year * general anesthesia for arthroscopic shoulder surgery in the beach-chair position

Exclusion criteria

* Congestive heart failure, coronary artery occlusive disease * Bradycardia \< 50 BPM, 2nd degree \< AV block * Poorly controlled hypertension * ß blocker medication * Coagulopathy * Pregnancy, nursing

Design outcomes

Primary

Measure	Time frame	Description
Regional cerebral oxygen saturation value	T1,T2,T3, T4, T5,T6, T7, T8, T9 time of post-dose during surgery	Before the anesthetic induction(T1), Before endotracheal intubation(T2), After endotracheal intubation(T3), Before the beach-chair position(T4), 5 minutes after the beach-chair position(T5), Before the operation(T6), 5 minutes after the incision(T7), After removal of the arthroscopy(T8), at the end of the operation(T9)

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026