Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study

Differential Effects of Total Cholesterol, Non-HDL Cholesterol and Triglycerides on Initial Presentation of Specific Cardiovascular Diseases (a CALIBER Study)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01687686

Enrollment

175872

Registered

2012-09-19

Start date

2001-01-31

Completion date

2012-12-31

Last updated

2012-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction Not Otherwise Specified, Non ST Elevation Myocardial Infarction, Stable Angina, ST Elevation Myocardial Infarction, Unstable Angina

Brief summary

The role of lipids as risk factors for cardiovascular events is well-documented, although events studied have largely been broad classes without specific detail. This study will examine a more refined set of endpoints.

Detailed description

The role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. The Emerging Risk Factors Collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (CHD) death; ischaemic, haemorrhagic and unclassified stroke. They also found that triglycerides concentration was not independently related with CHD risk after controlling for HDL cholesterol (HDL-C), non-HDL-C, and other standard risk factors. The Prospective Studies Collaboration found that Higher HDL-C and lower non-HDL-C levels were approximately independently associated with lower ischaemic heart disease mortality. By focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (CVD) phenotypes, disease progression and mortality from cardiovascular causes. With linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of CVD phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

* Aged 30 to 100, had at least one year of electronic health record data which meet General Practice Research Database data quality standards

Exclusion criteria

* No record indicating any cardiovascular disease phenotypes

Design outcomes

Primary

Measure	Time frame	Description
Rate of stable angina	Cohort followed up for average of 7 years	Incidence of stable angina in study population

Secondary

Measure	Time frame	Description
Rate of unstable angina	Cohort followed up for average of 7 years	Incidence of unstable angina in study population

Other

Measure	Time frame	Description
Rate of non ST elevation myocardial infarction	Cohort followed up for average of 7 years	Incidence of non ST elevation myocardial infarction

Countries

United Kingdom

Outcome results