Fetal Cardiac Rhythm Abnormalities
Conditions
Keywords
epidural analgesia, fetal cardiac rythm, ropivacaine, sufentanil
Brief summary
The aim of the investigators study is to demonstrate the association between fetal cardiac rhythm abnormalies after epidural analgesia and the maternal systemic transfer of ropivacaine and/or sufentanil.
Interventions
DRUGropivacaine
Sponsors
University Hospital, Rouen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years old or more * nulliparous \_ one fetus * head first * spontaneous labor * epidural analgesia * no fetal cardiac rhythm abnormalies before the epidural analgesia * no active management of labor during 30 minutes after the epidural analgesia induction * at term * signature of the consent form
Exclusion criteria
* pathological pregnancy * low maternal blood pressure during the 30 minutes after the epidural analgesia * uterin contraction which last for 5 minutes or more * more than 6 uterin contractions during a 10 minutes period * Ropivacaine contraindication * sufentanil contraindication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasmatic concentrations compared maternal ropivacaine based on the presence of abnormal fetal heart rate | 1 day | Maternal Plasmatic concentrations of ropivacaine will be measured in mg / liter of maternal blood and the median of each group will be compared by paired Wilcoxon test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasmatic concentrations compared maternal sufentanil based on the presence of abnormal fetal heart rate | 1 day | Maternal Plasmatic concentrations of sufentanil will be measured in mg / liter of maternal blood and the median of each group will be compared by paired Wilcoxon test |
Countries
France
Outcome results
None listed