Major Depressive Disorder
Conditions
Keywords
Major Depressive Disorder (MDD), Suicidality, Incarcerated Populations, Prisons, Interpersonal Psychotherapy (IPT)
Brief summary
This study will examine the effects of a first-line treatment for major depressive disorder (MDD), interpersonal psychotherapy (IPT), among men and women prisoners.
Detailed description
The purpose of this 3-year randomized trial is to promote uptake of evidence-based treatment in criminal justice settings by conducting a fully-powered randomized effectiveness study that collects pilot implementation data, including cost-effectiveness data. Group IPT will be compared to treatment as usual (TAU) in a sample of 90 male and 90 female prisoners with MDD from 4 institutions, allowing us to explore gender effects.
Interventions
BEHAVIORALGroup IPT for Depression + TAU
Interpersonal psychotherapy (IPT) will be administered in 20 group 90-minute sessions over 10 weeks and 4 individual sessions (before group starts, in the middle of the group, at the end of the group, and one month after the group ends). These sessions will focus on improving your relationships with others, building healthy relationships, setting goals, and increasing coping skills. Additionally, participants will receive standard prison mental health treatment, individual therapy, medication, etc.
Sponsors
National Institute of Mental Health (NIMH)
Brown University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Meet all DSM-IV criteria for primary (non-substance induced) major depressive disorder * Expectation of at least 6 months of incarceration at baseline interview * Incarcerated for at least 4 weeks
Exclusion criteria
* Lifetime: * Bipolar disorder * Psychotic disorder * Are imminently suicidal * Cannot understand English well enough to understand the consent form or assessment instruments when read aloud
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline in Hamilton Rating Scale for Depression (HRSD) at 3 Months | 3 Months from Baseline |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline in In-Prison Functioning at 3 Months | 3 Months from Baseline | In-prison functioning will be assessed by the number of correctional programs enrolled/completed and disciplinary/incident reports (measured by the Timeline Followback); aggression/victimization (measured by the Conflict Tactics Scale 2); social support (measured by the Multidimensional Scale of Perceived Social Support and the UCLA Loneliness Scale) |
| Change from Baseline in Hamilton Rating Scale for Depression (HRSD) at 6 Months | 6 Months from Baseline | — |
| Change from Baseline in Suicidality at 3 Months | 3 Months from Baseline | Suicidality as measured by the Beck Scale for Suicide Ideation. |
| Change from Baseline in In-Prison Functioning at 6 Months | 6 Months from Baseline | In-prison functioning will be assessed by the number of correctional programs enrolled/completed and disciplinary/incident reports (measured by the Timeline Followback); aggression/victimization (measured by the Conflict Tactics Scale 2); social support (measured by the Multidimensional Scale of Perceived Social Support and the UCLA Loneliness Scale) |
| Cost-effectiveness | 6 months post-baseline | Cost-effectiveness based on costs of IPT and TAU, improvements in HRSD scores, LIFE scores, and cost-offsets, including medical costs, programs completed, fewer fights, fewer suicide attempts, and reduced length of incarceration due to more good time. |
| Change from Baseline in Suicidality at 6 Months | 6 Months from Baseline | Suicidality as measured by the Beck Scale for Suicide Ideation. |
Countries
United States
Outcome results
None listed