Nausea, Vomiting
Conditions
Keywords
Nausea, vomiting, gastrointestinal symptoms, palliative care
Brief summary
This will be a blinded study to compare the absorption of topical haloperidol with placebo
Interventions
0.5 mg iv x one dose
0.5 mg iv , one dose
Sponsors
Study design
Eligibility
Inclusion criteria
* Age: patient must be 18 years or older and less than 70 years of age. * Provision of informed consent * No previous adverse reaction to haloperidol * No current use of haloperidol * Good health * No alcohol within 24 hours of the study * No significant cardiovascular, gastrointestinal, hematologic, neurologic, renal, hepatic or pulmonary disease. * Normal neurologic exam Exclusionary Criteria * Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study * Recent cerebral trauma * Study will exclude women who are pregnant and/or nursing * Women who are of child bearing potential must have a negative urine pregnancy test. * History of seizures * Taking medications that can interact with haloperidol * Subjects with significant cardiovascular (cardiac conduction deficits), gastrointestinal, hematologic, neurologic, renal, hepatic or pulmonary disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To measure the pharmacokinetics levels of haloperidol after topical administration compared with intravenous administration. | baseline to 240 minutes after administration. | Measuring either the presence of absence of haloperidol |