Morbid Obesity
Conditions
Keywords
abdominal adipose tissue; microRNA
Brief summary
To investigate: 1. Associations between miRNA and insulin signaling-related gene expressions in abdominal adipose tissues in obese subjects. 2. Differences in miRNAs expressed by intrabdominal omental adipose tissues between genders.
Detailed description
Compared the differences in microRNA expressions of abdominal adipose tissue in morbid obese male and female subjects to elucidate the possible regulatory role of microRNA in insulin signaling-related gene expression levels and its association with biochemical markers. We hope to find a miRNA that can be used to predict the syndrome associated with obesity.
Interventions
GENETICgender
Paired samples of abdominal subcutaneous and intrabdominal omental adipose tissue were obtained from men and women who underwent bariatric surgery.
Sponsors
National Science and Technology Council, Taiwan
Sung Ling Yeh
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
19 Years to 63 Years
Healthy volunteers
No
Inclusion criteria
* Morbid obesity,BMIs\> 40 kg/m2 * Subjects who underwent bariatric surgery
Exclusion criteria
* Obese subjects with complicated metabolic disorders * Thyroid disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MicroRNA expression in abdominal omental adipose tissues | up to 28 weeks | MicroRNA-125a-3p expression in abdominal omental adipose tissues is associated with insulin signaling-related gene expression levels in morbid obesity |
Countries
Taiwan
Outcome results
None listed