Stroke, Transient Ischemic Attack
Conditions
Keywords
Stroke, Ischemic Attack, Transient, Medication adherence, Motivational interviewing, Stroke prevention
Brief summary
Patient suffering a Transient Ischemic Attack (TIA) or stroke are subsequently at high risk of a new stroke, however, poor adherence to secondary prevention medications occurs frequently within this patient group. The purpose of this study is to evaluate whether a complex tailored pharmacist intervention will lead to increased adherence to secondary stroke prevention medications and less new stroke events when compared to a usual care group. Interventions focus on motivational interviewing, medication review and telephone follow up.
Interventions
BEHAVIORALComplex tailored intervention
BEHAVIORALUsual care
Sponsors
University of Southern Denmark
Odense University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age: 18 years or older * Patient admitted or receiving ambulatory treatment for an acute transient ischemic attack or ischemic stroke which has occurred within the previous 30 days. * The patient or a carer usually dispenses the patient's medications * Written consent
Exclusion criteria
* Cognitive or physical impairment that would preclude comprehension of a conversation * Terminal illness * Lives in a care home or an institution * Receives dose dispensed medicine from a pharmacy * Medicine is dispensed by a nurse in the patient's home * Correctional mental health patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Medication Adherence to antiplatelets, anticoagulants and statins measured by proportion of days covered (PDC). | One year from inclusion |
| For antiplatelets, anticoagulants and statins: Percent of patients that are at least 80% adherent (PDC>0.8) | 1 year from inclusion |
Secondary
| Measure | Time frame |
|---|---|
| Non-persistence with thromboprophylactic agents ( antiplatelets, anticoagulants, statins and antihypertensives) measured by percent of patients that are not supplied with medication for more than 3 continuous months | One year from inclusion |
| Medication Adherence to antihypertensives measured by proportion of days covered (PDC) | One year from inclusion |
| Composite endpoint: stroke, myocardial infarction or cardiovascular death | One year from inclusion |
| Accept rate for thromboprophylactic agents measured by percent of patients starting treatment within 0-90 days after discharge. | 3 months from discharge |
| Percent of patients that are at least 80% adherent (PDC>0.8) to antihypertensives | One year from inclusion |
Countries
Denmark
Outcome results
None listed