Critical Illness
Conditions
Keywords
oxygen, critical illness, mechanical ventilation
Brief summary
The investigators hypothesize that it is feasible and safe to deliver a conservative approach to oxygen therapy in mechanically ventilated critically ill patients (a tiem frame of, on average,10 days).
Detailed description
1. Identify patients likely to require ventilation until the day after tomorrow (a time frame of 36 hours of average) 2. Deliver a conservative oxygen therapy protocol while in ICU (a time frame on average of 10 days) 3. Target an oxygen saturation between 90 and 92% 4. Adjust FiO2 to achieve target SaO2 at all times 5. Assess percentage of time patient is within target 6. Assess for safety of this approach
Interventions
OTHERstandard care
OTHERconservative O2 therapy
target lower O2 saturation
Sponsors
Austin Health
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Mechanical ventilation * expected to be ventilated until the day after tomorrow (a tiem frame of, on average 48 hours)
Exclusion criteria
* expected to be off mechanical ventilation today or tomorrow * carbon monoxide poisoning * necrotizing fasciitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in PaO2/FiO2 ratio from baseline to worst value | 10 days | Pao2/FiO2 ratio will be measured regularly and compared during standard care and the intervention period (a time frame of, on average, 10 days) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lactate | 10 days | blood lactate will be measured regularly and assessed during standard care and the intervention period |
Other
| Measure | Time frame | Description |
|---|---|---|
| arrhythmias | 10 days | patients will have continuous ECG monitoring and arrhythmias will be recorded in the two groups |
Countries
Australia
Outcome results
None listed