Infertility, PCOS
Conditions
Keywords
OHSS, mataphase II oocytes (MII), good quality embryo's, pregnancy
Brief summary
In this study the investigators compare the traditional way of triggering with a new way in patients with Poly Cystic Ovary Syndrome (PCOS). This to reduce the risque of Ovary Hyper Stimulation Syndrome (OHSS) in In Vitro Fertilization/ IntraCytoplastic Sperm Injection (IVF/ ICSI) treatment. The investigators also compare the number of mature oocytes, embryo's and pregnancy rate.
Interventions
DRUGGnRh agonist +1500E hCG
ovulation induction with GnRh agonist and 1500E hCG one hour after egg retrieval
Sponsors
Onze Lieve Vrouw Hospital
AZ Jan Palfijn Gent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
* ICSI patients below 38 years * 1, 2 and 3e IVF cycle * Body Mass Index (BMI) less than 32 * PCOS patients
Exclusion criteria
* endocrinal diseases or problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MII oocytes | patients will be followed during the stimulation with an average of 10 days | The number of mature oocytes retrieved after stimulation without creating OHSS |
| 2 Pro Nuclei (2PN) fertilization | 24h after ICSI | laboratory follow up of the fertilized egg during the first 24h |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| implantation rate | 12 weeks | The number of pregnancies obtained wich still is the most important issue for the patients |
| OHSS | one month with oocyte retrieval in the middle | patient follow up according to subjective complaints and objective measures |
Countries
Belgium
Outcome results
None listed