Infertility
Conditions
Brief summary
We would like to determine if HBA® testing of sperm in couples with presumed idiopathic infertility will reveal lower binding percentages than in couples with an identifiable cause of infertility either male factor or tubal factor
Detailed description
We would like to determine if HBA® testing of sperm in couples with presumed idiopathic infertility will reveal lower binding percentages than in couples with an identifiable cause of infertility either male factor or tubal factor We would like to determine if patients with abnormal HBA binding have decreased IVF outcome: decreases clinical pregnancy rate, implantation rate, and increased miscarriage rate
Interventions
OTHERHBA binding assay
HBA binding assay will be preformed on the discarded portion of semen analysis used for IVF.
Sponsors
St. Luke's-Roosevelt Hospital Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* . All groups will include females under 40 years of age undergoing 1st IVF cycle 3 groups 1. Abnormal Semen Analysis (sperm count \<10 million/ml and /or rapid progressive motility \< 50 %, WHO morphology \<30%) normal HSG , normal ovarian reserve testing and ovulation testing 2. Unexplained infertility- normal ovarian reserve testing and ovulation testing (FSH\< 10, AMH\>1.0) Normal ovulatory cycles, normal WHO semen analysis. Normal tubes on HSG or Laparoscopy 3. Tubal infertility as assessed by HSG or laparoscopy
Exclusion criteria
* women over 40, prior failed IVF
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In each of these groups we will assess presence of HBA bound sperm | immediate at time of preforming HBA test |
Countries
United States
Outcome results
None listed