Descemet's Stripping Endothelial Keratoplasty, Endothelial Dystrophy, Posterior Lamellar Keratoplasty, Secondary Bullous Keratopathy
Conditions
Brief summary
After corneal transplantation, topical corticosteroids are used to reduce the risk of rejection. However, the optimal postoperative treatment regimen is unknown. In most cases, a topical steroid is administered for at least 6 months after surgery, but it remains to be determined whether potent steroids offer better protection than weak steroids. Also, the length of the treatment is debated. Since the use of steroids is not without potential serious ocular side effects, it is of considerable importance to investigate these problems. The study aims to examine the frequency of rejection episodes after posterior lamellar keratoplasty; specifically comparing a short course of potent steroids versus a long course of weak steroids.
Interventions
DRUGWeak steroid (Flurolon, Allergan)
DRUGPotent steroid (Maxidex, Alcon)
Sponsors
Aarhus University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients treated for primary or secondary corneal endothelial failure at the department of ophthalmology, Aarhus University Hospital
Exclusion criteria
* Not fulfilling the above
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Freedom from rejection | 2 years |
Countries
Denmark
Outcome results
None listed