Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV)

Collection of Whole Blood Specimens and Buccal Swabs From Subjects Diagnosed With CNV AMD, Dry AMD, and Age-Matched Controls to Assess the Association of Genetic Variants in Complement Factor H With Risk of Progression to CNV.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01682382

Enrollment

Registered

2012-09-10

Start date

2012-08-31

Completion date

2013-10-31

Last updated

2014-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age-related Macular Degeneration, Choroidal Neovascular Age-related Macular Degeneration

Keywords

age-related macular degeneration, choroidal neovascular age-related macular degeneration, genetics, macular pigment optical density (MPOD)

Brief summary

Subjects with wet AMD, dry AMD, and age-matched controls will undergo routine occular measurements, will provide a blood and cheek cell sample, and will have macular pigment optical density (MPOD) measured to determine if there is an association between genetics, MPOD and the risk of progression to wet AMD.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* subject is diagnosed with either CNV, dry AMD or is an age-matched control * self reported as non-Hispanic Caucasian * 60 years of age or older * provides signed and dated informed consent * agrees to provide 10 mL of whole blood and two buccal swabs

Exclusion criteria

* previous donation under this protocol

Design outcomes

Primary

Measure	Time frame	Description
Association between a genetic variant in the CFH gene and risk of progression to CNV	Baseline	DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate a genetic variant in the CFH gene and its association with risk of progression to CNV

Secondary

Measure	Time frame	Description
Genetic correlation between MPOD and risk of progression to CNV	baseline	DNA extracted from blood and buccal cells collected from subjects with either CNV, dry AMD, and age-matched controls will be analyzed to investigate the correlation between genetics, MPOD, and risk of progression to CNV

Countries

United States

Outcome results