Cardiac Surgery
Conditions
Keywords
cardiac surgery, Pulse pressure variation, intravenous fluids
Brief summary
We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such patients in the first 24 hours after surgery
Detailed description
1. The investigators will study patients after cardiac surgery 2. The investigators will collect data on standard care in pre-intervention population 3. The investigators will collect demographic and clinical data 4. The investigators will collect biochemical data in the first 24 hours after surgery 5. The investigators will collect biochemical, physiological and clinical outcome data 6. The investigators will compare the standard care and intervention period data
Interventions
OTHERIV fluid according to PPV
intravenous fluids
OTHERfluids according to standard care
Sponsors
Austin Health
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. immediately after ICU admission after cardiac surgery 2. mandatory mechanical ventilation -
Exclusion criteria
1. Pressure support ventilation 2. ECMO 3. Intra-aortic balloon counterpulsation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean amount of fluid given in the first 24 hours after surgery | 24 hours | all intravenous fluid administered |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physiological outcome | 24 hours | Blood lactate |
Other
| Measure | Time frame | Description |
|---|---|---|
| Physiological outcome | 24 hours | cardiac index |
Countries
Australia
Outcome results
None listed