Quality of Life for Geriatric Patients.
Conditions
Keywords
autosuggestion, quality of life, geriatric, serum cortisol, Interferon gamma, interleukin-2, interleukin-6, neuroplasticity
Brief summary
The objective is to analyze the efficacy of autosuggestion for geriatric patients's quality of life and its impact to psycho-neuro-endocrine-immune pathways. The primary outcome is quality of life. The hypothesis of this study is that autosuggestion will increase geriatric patient's quality of life based on its impact to psycho-neuro-endocrine-immune pathways.
Detailed description
Geriatric patients diagnosed with multipathology after getting information and signing informed consent will be included in this trial. Autosuggestion was created by patients according to their preferences, modified by researcher to accomplish autosuggestion principles, recorded in a tape to be heard by walkman daily for 30 days. Intervention and control groups received usual standard medical therapy. Baseline data were collected within one week after admission. Then the subject will be followed up for 30 days. Primary outcome was quality of life measured by COOP chart, analyze using on treatment analysis. Secondary outcomes were serum cortisol, interleukin-2, interleukin-6, IFN-ϒ (Interferon gamma), and N Acetyl Aspartat/ creatine ratio in limbic and paralimbic system by Magnetic Resonance Spectroscopy.
Interventions
BEHAVIORALAutosuggestion for 30 days
Sponsors
Indonesia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age: ≥ 60 years old with multipathology, inpatients * Not in steroid therapy * Could communicate (Karnofsky score: 40% or Zubrod/WHO score: 3) * Cooperative * Willing to go through all of the research steps.
Exclusion criteria
* Stroke * Multiple Sclerosis * Brain Tumour * Using Pace maker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of Life | 30 days | Measured by COOP chart |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Interferon Gamma (pg/mL) | 30 days | Change from baseline in Interferon Gamma concentration (pg/mL) measured by ELISA method at 08.00-09.00 am. |
| Interleukin-6 (pg/mL) | 30 days | Change from baseline in Interleukin-6 concentration(pg/mL) measured by ELISA method at 08.00-09.00 am. |
| Serum Cortisol (ng/mL) | 30 days | Change from baseline in Serum Cortisol concentration (ng/mL) measured by Radioimmunoassay method at 08.00-09.00 am. |
| Interleukin-2 (pg/mL) | 30 days | Change from baseline in Interleukin-2 concentration (pg/mL) measured by ELISA method at 08.00-09.00 am. |
| N Acetyl Aspartat/ creatine ratio in limbic and paralimbic system (amygdala, hippocampus, hypothalamus, temporal lobe, accumbens nuclei, prefrontal cortex) | 30 days | Ratio change from baseline by Magnetic Resonance Spectroscopy. |
Countries
Indonesia
Outcome results
None listed