Adenosine-induced Stress Dynamic Myocardial Perfusion Imaging With Dual-source CT

Status

Terminated

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01680081

Enrollment

Registered

2012-09-06

Start date

2012-01-30

Completion date

2016-07-11

Last updated

2019-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Brief summary

This study was designed as a prospective multicenter trial to determine the accuracy of combined CT coronary angiography and perfusion imaging, specifically quantitative dynamic perfusion imaging in patients with suspicious coronary artery disease compared conventional coronary angiography and quantitative dynamic perfusion MRI as standard reference.

Interventions

OTHERAdenosine stress dynamic CT perfusion

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. Men and women patients, with age ranging 40-80. 2. Suspected coronary artery disease who are supposed to undergo invasive coronary angiography with appropriate clinical indications 3. Patients who are willing to sign the informed consent form

Exclusion criteria

1. Contraindication of CT Known allergy to iodinated contrast media or history of contrast-induced nephropathy Decreased renal function: elevated serum creatinine(\>1.5mg/dl) Contraindication to beta-blockers Severe arrhythmia: arterial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block) 2. Contraindication of MRI Claustrophobia Metallic hazards Pacemaker implant eGFR\<30 ml/min 3. Unstable or uncooperative patients 4. Limited life expectancy due to cancer or end-stage renal or liver disease 5. Evidence of severe symptomatic heart failure (NYHA Class III or IV) 6. Previous myocardial infarction, coronary artery intervention, coronary artery bypass surgery, or other cardiac surgery

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic accuracy of stress induced CT perfusion	10-30 days	Diagnostic accuracy of combined stress and rest dynamic CT perfusion and coronary angiography with dual x-ray sources in detection of hemodynamically significant stenosis of coronary artery compared with conventional coronary angiography and perfusion MRI in patients with suspicious coronary artery disease.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026